Relationship between vitamin D receptor gene polymorphisms and anemia in postmenopausal Vietnamese women

Background: Both in vitro and in vivo studies have shown that calcitriol, the active form of vitamin D, is involved in hematopoiesis. Vitamin D receptor (VDR) gene has been suggested as one of the candidate genes for anemia.Objective: Investigate relationship between anemia and the commonly studied polymorphisms of VDR gene (FokI, BsmI, ApaI and TaqI) in terms of genotype and haplotype in Vietnamese.Methods: A case-control study including 132 postmenopausal women without chronic kidney diseases was designed to investigate the relationship between VDR polymorphism and anemia. Four single nucleotide polymorphisms (SNPs) FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were typed bypolymerase chain reaction and restriction fragment length polymorphism method.Results: Genotype distributions of four SNPs were in Hardy-Weinberg equilibrium in both anemia and control groups. The SNPs at the 3’end of the VDR gene (BsmI, ApaI and TaqI) exhibited a strong linkage disequilibrium. There was no significant association between anemia and VDR polymorphism in terms of allele, genotype, andhaplotype in the analyses unadjusted or adjusted for the covariates (age, body mass index, educational level, serum ferritin, iron and albumin).Conclusion: VDR gene did not influence anemia in postmenopausal women without chronic kidney disease. For further study on the association between VDR gene and anemia, the use of larger sample size, a prospective study design, and additional markers would enhance the reliability and validity of findings.Keywords: Anemia, association, haplotype, postmenopausal Vietnamese women, vitamin D receptor

Under 6- month- old infants in Vietnam have high risk of vitamin A deficiency

The study was performed on 4 areas (Northern plain, Northern mountain, Southern of Centre, MeKong delta) with 10 communes for each areas. In each commune, 50 under 5 years old children and 15-20 mother-infant pairs of first year breastfeeding. Preclinical deficiency of vitamin A in under 6 months infant group accounts for 32.7%, in other groups 12.4%. Low concentration of vitamin A in breast milk was the most important risk factor, leading to low level of serum vitamin A (SVAL). Taking vitamin A capsule can raise SVAL, reduce the incidence of preclinical deficiency of vitamin A. Malnutritional infant of the scinting form, last month respiratory inflammation significant asiveiation with low level of vitamin A in serum

Fundamental theory and the use of nutritional prophylaxis in preventing chronic diseases

To evaluate the important role of various kinds of food/diet for health in order to prevent the chronic diseases. Suitable nutrition is not only aiming at previous nutrition but also base on various kinds of food. A fulfill multinutrition source from plant is needed for a diet. 400 g vegetable/day will provided at least 7% energy/day. The mainly energy source are based on raw provisions that in less process. Limitation of sweet sugar, powder with high blood sugar level. The sugar amount usage isn’t more than 10% energy per day. The red meat doesn’t use over 10% energy/day. Domestic fowls should be in priority eaten. Salt in each portion isn’t over 6g per adult. No alcohol drinking and in the case of drinking it , the limitation is under 5% of energy for man and 2,5% for woman